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Trace-element concentrations in human autopsy tissue.

T G Aalbers1, J P Houtman, B Makkink

  • 1Interuniversity Reactor Institute, Delft, The Netherlands.

Clinical Chemistry
|November 1, 1987
PubMed
Summary
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This study analyzed trace element concentrations in human organs from 200 autopsies. Findings reveal distinct element distributions, highlighting organ-specific storage processes.

Area of Science:

  • Human physiology
  • Analytical chemistry
  • Toxicology

Background:

  • Trace elements are vital for human health.
  • Understanding their distribution in organs is crucial for diagnostics and toxicology.
  • Previous studies have limitations in methodology and scope.

Purpose of the Study:

  • To quantify trace-element concentrations in human heart, liver, kidney, aorta, and rib.
  • To meticulously detail sampling and analysis procedures, addressing potential errors.
  • To investigate the distribution patterns of these elements within specific organs.

Main Methods:

  • Neutron activation analysis (NAA) was employed for precise quantification.
  • Rigorous attention was paid to sampling protocols to minimize contamination and ensure homogeneity.

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  • Statistical analysis of concentration data (averages, standard deviations, ranges) was performed.

    • Main Results:

    • Concentration data for 20 elements (As, Ca, Cd, Cl, Co, Cr, Cu, Fe, Hg, K, Mg, Mn, Mo, Na, Ni, Pb, Rb, Sb, Se, Zn) were established.
    • Three distinct distribution patterns of elements across organs were identified.
    • Variations in element concentrations were observed between different organs.

    Conclusions:

    • The identified distribution patterns suggest specific organ-based storage mechanisms for certain elements.
    • This data provides a foundation for understanding element homeostasis and potential toxicological implications.
    • Methodological rigor is essential for accurate trace-element analysis in biological samples.