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Obesity and Coronavirus Disease 2019
Sijia Fei1,2, Xinyuan Feng1,2, Jingyi Luo1
1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Journal of Translational Internal Medicine
|February 13, 2023
Summary
Obesity worsens COVID-19 outcomes, increasing hospitalization and mortality risks. Understanding obesity
Area of Science:
- Public Health
- Infectious Diseases
- Metabolic Disorders
Background:
- The COVID-19 pandemic presents significant global health challenges.
- Obesity is increasingly recognized as a critical factor influencing COVID-19 severity.
Purpose of the Study:
- To investigate the multifaceted role of obesity in COVID-19 incidence and progression.
- To explore the psychosocial impacts and optimal management strategies for obese COVID-19 patients.
Main Methods:
- Literature review and synthesis of existing research on obesity and COVID-19.
- Analysis of mechanisms linking obesity to severe COVID-19 outcomes.
- Evaluation of treatment and management approaches for affected individuals.
Main Results:
- Obesity exacerbates COVID-19, correlating with higher ICU admission, mechanical ventilation needs, and mortality.
- Key interaction mechanisms include inflammation, immune dysregulation, altered pulmonary dynamics, receptor disruptions, and endothelial dysfunction.
- Obesity and comorbidities significantly impact disease severity and patient prognosis.
Conclusions:
- Comprehensive evaluation of obesity degree and comorbidities is crucial for COVID-19 patients.
- Prompt initiation of anticoagulants, anti-inflammatories (e.g., glucocorticoids), and airway management is recommended.
- Long-term prognosis, vaccine efficacy, and psychosocial support are essential components of care for obese individuals during and after the pandemic.
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