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Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial

Carmen Tarifa1,2, Alexander Vallmitjana3, Verónica Jiménez-Sábado1,2,4

  • 1Instituto de Investigaciones Biomédicas de Barcelona, IIBB-CSIC, Barcelona, Spain.

JACC. Basic to Translational Science
|February 13, 2023
PubMed

Keywords:
AF, atrial fibrillationCsq-2, cardiac calsequestrin (type 2)ICa, calcium currentITI, transient inward currentNCX-1, cardiac Na+/Ca2+ exchanger (type 1)PLB, phospholambanRyR2, cardiac ryanodine receptor (type 2)SERCA2a, cardiac sarcoplasmic reticulum Ca-ATPase pump protein (type 2)SR, sarcoplasmic reticulumatrial fibrillationhuman atrial myocyteryanodine receptorsarcoplasmic reticulumtransient inward currents

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