Related Experiment Video
Updated: Aug 13, 2026

17:28
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
Maize Adh1 as a monitor of environmental mutagens
Environmental Health Perspectives
|December 1, 1978
Abstract:
The maize Adh1 gene is introduced, with citations. The use of this gene as a mutagen monitor is discussed, with emphasis on differentiating quantitative and qualitative parameters. A proper assessment of hazard from environmental pollutants requires data on possible mutagen specificities for different kinds of DNA.
Related Concept Videos
Mismatch Repair
Overview
Mutagenicity and Carcinogenicity
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Spontaneous and Induced Mutations
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).

