Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Stability01:53

RNA Stability

33.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.8K
Mitochondria01:37

Mitochondria

14.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.1K
Replication in Eukaryotes01:29

Replication in Eukaryotes

14.1K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
14.1K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K
Telomeres and Telomerase02:41

Telomeres and Telomerase

23.6K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
23.6K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.0K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis of clinical characteristics of renal oncocytoma: 26 cases report].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2012
Same author

[Expression of Na+/H+ antiporter gene KsNHX1 in Kochia sieversiana under saline-alkali stress].

Ying yong sheng tai xue bao = The journal of applied ecology·2012
Same author

Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.

International journal of molecular sciences·2012
Same author

[Analysis of genes and genetic susceptibility of olfactory disorders].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2012
Same author

Top-down processing of symbolic meanings modulates the visual word form area.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2012
Same author

Oxidative stress acts on special membrane proteins to reduce the viability of Pseudomonas syringae pv tomato.

Journal of proteome research·2012
Same journal

RNA Modifications as Drug Targets: Unlocking the Therapeutic Potential of the Epitranscriptome.

Current genomics·2026
Same journal

AgriBioNER: A Named Entity Recognition Tool for Identification of ncRNA and Diseases in Agricultural Literature.

Current genomics·2026
Same journal

Understanding the Evolutionary Adaptations and the Associated Functional Dynamics of Diatom <i>Cyclotella Cryptica</i>: A Chloroplast Genome-wide Comparative Study.

Current genomics·2026
Same journal

The Role of Collagen Genetic Variability in Degenerative Disc Disease and Related Conditions.

Current genomics·2026
Same journal

Genomics-Driven Immunotherapy: Advancing Cancer Treatment through Personalized Approaches.

Current genomics·2026
Same journal

Innovative Applications and Challenges of Isothermal Amplification Technology in miRNA Detection.

Current genomics·2026
See all related articles

Related Experiment Video

Updated: Aug 10, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.3K

Circular RNA Involvement in Aging and Longevity.

Ruize Niu1, Jia Liu1

  • 1Laboratory Zoology Department, Kunming Medical University, Kunming 650500, Yunnan, China.

Current Genomics
|February 13, 2023
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are key regulators of aging and longevity. These molecules show differential expression across species and tissues, highlighting their potential as biomarkers and therapeutic targets for age-related conditions.

Keywords:
Agingage-related diseasesbiomarkerscircular RNAlongevitymicroRNAs

More Related Videos

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.5K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.4K

Related Experiment Videos

Last Updated: Aug 10, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.3K
The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.5K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.4K

Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • Circular RNAs (circRNAs) are generated by back-splicing of exons from protein-coding genes.
  • Massive numbers of circRNAs are differentially expressed across species, suggesting roles in aging.

Purpose of the Study:

  • To review the literature on the role of circRNAs in aging and longevity.
  • To explore circRNAs as potential biomarkers and regulators of the aging process.

Main Methods:

  • Literature review focusing on circRNAs in relation to tissue senescence and individual longevity.
  • Analysis of studies investigating circRNAs in model organisms and mammalian tissues.

Main Results:

  • circRNAs modulate aging and longevity pathways in invertebrates like *Caenorhabditis elegans* and *Drosophila*.
  • circRNAs regulate age-related processes in mammalian tissues including brain, serum, heart, and muscle.
  • Specific circRNAs (circSfl, circGRIA1, circNF1-419) are linked to aging and longevity.

Conclusions:

  • circRNAs play significant roles in both aging and longevity.
  • circRNAs are promising biomarkers for aging and potential regulators for interventions.
  • Further research into circRNAs could unlock new strategies for promoting healthy aging.