Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

2.9K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.9K
Viral Structure00:56

Viral Structure

62.9K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.9K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

2.4K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.4K
Introduction to Virus01:28

Introduction to Virus

123
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
123
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.6K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.6K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

5.3K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity.

Communications biology·2026
Same author

Vimentin molecular linkages with nesprin-3 enhance nuclear deformations by cell geometric constraints.

Scientific reports·2026
Same author

Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: Single-center cohort analysis.

The Journal of allergy and clinical immunology·2026
Same author

Obstructed supracardiac TAPVC with atretic common pulmonary vein and dual vertical veins: Clinical and postmortem correlation in a term neonate.

Forensic science, medicine, and pathology·2026
Same author

Multi-Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Cell strain-stiffening drives cell breakout from embedded spheroids.

ArXiv·2026

Related Experiment Video

Updated: Aug 10, 2025

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
09:08

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

3.8K

How cells wrap around virus-like particles using extracellular filamentous protein structures.

Sarthak Gupta1, Christian D Santangelo1, Alison E Patteson1

  • 1Physics Department and BioInspired Institute, Syracuse University Syracuse, NY USA.

Biorxiv : the Preprint Server for Biology
|February 13, 2023
PubMed
Summary

Cells with optimal filamentous extracellular components (ECCs) enhance viral entry via faster, more efficient surface folding during endocytosis. This suggests ECCs influence viral infection dynamics and evolution.

More Related Videos

Averaging of Viral Envelope Glycoprotein Spikes from Electron Cryotomography Reconstructions using Jsubtomo
08:29

Averaging of Viral Envelope Glycoprotein Spikes from Electron Cryotomography Reconstructions using Jsubtomo

Published on: October 21, 2014

12.3K
Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion
05:43

Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion

Published on: January 24, 2017

14.6K

Related Experiment Videos

Last Updated: Aug 10, 2025

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
09:08

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

3.8K
Averaging of Viral Envelope Glycoprotein Spikes from Electron Cryotomography Reconstructions using Jsubtomo
08:29

Averaging of Viral Envelope Glycoprotein Spikes from Electron Cryotomography Reconstructions using Jsubtomo

Published on: October 21, 2014

12.3K
Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion
05:43

Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion

Published on: January 24, 2017

14.6K

Area of Science:

  • Cell biology
  • Biophysics
  • Computational modeling

Background:

  • Endocytosis is a key cellular process for nanoparticle and viral uptake.
  • Previous research focused on nanoparticle size and shape, neglecting surface structures.
  • Extracellular vimentin and viral structures inspired modeling filamentous components.

Approach:

  • Developed a computational model incorporating filamentous protein structures on both cell and virus surfaces.
  • Studied the impact of these structures on the efficiency of viral wrapping during endocytosis.
  • Analyzed the role of cell surface bending rigidity and extracellular component stiffness.

Key Points:

  • Optimal density of filamentous extracellular components (ECCs) accelerates viral uptake and reduces cell surface area usage.
  • Efficient, fold-like wrapping of the virus by the cell surface occurs at optimal ECC density.
  • Cell surface bending rigidity promotes folding, while altered stiffness of ECCs or viral spikes can lead to crumple-like wrapping.

Conclusions:

  • Filamentous extracellular components significantly influence viral endocytosis dynamics.
  • The cellular microenvironment, including ECCs, may exert evolutionary pressure on virus-like particles.
  • Understanding these interactions is crucial for predicting viral infection and evolution.