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Pseudoangiomatous Stromal Hyperplasia: Radiologic-Pathologic Correlation.

Megan E Speer¹, Esther C Yoon², Wendie A Berg^3,4

¹The University of Texas MD Anderson Cancer Center, Department of Breast Imaging, Houston, TX, USA.

Journal of Breast Imaging

|February 13, 2023

Summary

This summary is machine-generated.

Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion often found incidentally. Imaging findings are nonspecific, requiring radiologic-pathologic correlation for accurate diagnosis and management.

Keywords:

PASH pseudoangiomatous hyperplasia radiologic-pathologic correlation

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Area of Science:

Breast Imaging
Pathology
Endocrinology

Background:

Pseudoangiomatous stromal hyperplasia (PASH) is a benign mesenchymal proliferation of the breast.
PASH is thought to be hormonally induced, affecting premenopausal women and those on hormone therapy.

Purpose of the Study:

To review the clinical, imaging, and histopathologic features of PASH.
To emphasize the importance of radiologic-pathologic concordance in PASH diagnosis.

Main Methods:

Review of clinical presentations, mammographic, ultrasound (US), and magnetic resonance imaging (MRI) findings.
Discussion of histopathologic features and differential diagnoses.
Emphasis on radiologic-pathologic correlation.

Main Results:

PASH presents variably, from subtle asymmetries to palpable masses.
Imaging findings are nonspecific across mammography, US, and MRI.
Histopathology can mimic other lesions, necessitating careful assessment.

Conclusions:

Accurate diagnosis of PASH relies on correlating imaging and pathology.
Discordant or suspicious findings may require biopsy or excision.
Concordant benign PASH diagnoses allow patients to resume routine screening.