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Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
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Genetically engineered mouse models of FK506-binding protein 5
Niat T Gebru1,2, Shannon E Hill1,2, Laura J Blair1,2,3
1USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA.
Journal of Cellular Biochemistry
|February 13, 2023
Summary
FKBP51, a protein influencing stress response and hormone receptor regulation, is crucial for understanding neuropsychiatric disorders. Mouse models of FKBP5 provide insights into its complex roles in metabolism and neuronal health.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- FKBP51 is a molecular chaperone involved in stress response and steroid hormone receptor regulation.
- Alterations in the FKBP5 gene are linked to neuropsychiatric disorder susceptibility.
- FKBP51 plays a role in metabolism and neuronal health.
Purpose of the Study:
- To review current mouse models of FKBP5.
- To discuss the generation and observational details of these models.
- To highlight the utility of mouse models in understanding FKBP51 biology.
Main Methods:
- Examination of whole animal knockout mouse models.
- Analysis of conditional knockout mouse models.
- Review of overexpression and humanized mouse models.
- Discussion of behavioral, molecular, and electrophysiological data.
Main Results:
- Mouse models offer valuable insights into FKBP51's function.
- Observed phenotypes include behavioral, molecular, and electrophysiological alterations.
- These models aid in understanding FKBP51's role in stress response and neuropsychiatric disorders.
Conclusions:
- FKBP5 mouse models are essential for advancing FKBP51 research.
- Further studies are needed to address remaining knowledge gaps.
- FKBP5 presents a promising therapeutic target for stress-related disorders.
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