Air pollution exposure and heart failure: A systematic review and meta-analysis

While the literature strongly supports a positive association between particulate matter with diameter ≤ 2.5 μm (PM_2.5) exposure and heart failure (HF), there is uncertainty regarding the other pollutants and the dose and duration of exposure that triggers an adverse response. To comprehensively assess and quantify the association of air pollution exposure with HF incidence and mortality, we performed separate meta-analyses according to pollutant types [PM_2.5, PM₁₀, sulfur dioxide (SO₂), nitrogen dioxide (NO₂), carbon monoxide (CO), ozone (O₃)], and exposure duration (short- and long-term). We systematically searched PubMed, EMBASE, and Web of Science for relevant articles with publication dates up to July 12, 2022, identifying 35 eligible studies. Random-effects models were used to summarize the pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs). For long-term exposure, the growing risk of HF was significantly associated with each 10 μg/m³ increase in PM_2.5 (OR = 1.196, 95 % CI: 1.079-1.326; I² = 76.8 %), PM₁₀ (1.190, 1.045-1.356; I² = 76.2 %), and NO₂ (1.072, 1.028-1.118; I² = 78.3 %). For short-term exposure, PM_2.5, PM₁₀, NO₂, and O₃ (per 10 μg/m³ increment) increased the risk of HF, with estimated ORs of 1.019 (1.008-1.030; I² = 39.9 %), 1.012 (1.007-1.017; I² = 28.3 %), 1.016 (1.005-1.026; I² = 53.7 %), and 1.006 (1.002-1.010; I² = 0.0 %), respectively. No significant effects of SO₂ and CO exposure on the risk of HF were observed. In summary, our study powerfully highlights the deleterious impact of PM_2.5, PM₁₀, and NO₂ exposure (either short- or long-term) on HF risk. Serious efforts should be made to improve air quality through legislation and interdisciplinary cooperation.