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Related Experiment Videos

Epidemiologic patterns in lung cancer by histologic type.

E L Wynder1, L S Covey

  • 1American Health Foundation, New York, NY 10017.

European Journal of Cancer & Clinical Oncology
|October 1, 1987
PubMed
Summary

Lung cancer cell types Kreyberg I and Kreyberg II show changing frequencies over time. Kreyberg II cases are increasingly common, particularly in younger demographics, suggesting real etiological shifts beyond smoking.

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Area of Science:

  • Oncology
  • Epidemiology
  • Public Health

Background:

  • Lung cancer exhibits diverse histological subtypes, including Kreyberg I and Kreyberg II.
  • Understanding trends in lung cancer cell type distribution is crucial for public health.
  • Previous studies have explored demographic associations with lung cancer subtypes.

Purpose of the Study:

  • To analyze secular trends in Kreyberg I and Kreyberg II lung cancer classifications.
  • To investigate demographic differences associated with Kreyberg I and Kreyberg II subtypes.
  • To identify potential etiological factors contributing to observed changes in lung cancer histology.

Main Methods:

  • Retrospective analysis of 3,097 lung cancer patients diagnosed between 1977-1984 in U.S. hospitals.
  • Classification of patients into Kreyberg I and Kreyberg II histological categories.
  • Statistical analysis to assess demographic variations and temporal trends, controlling for smoking.

Main Results:

  • Kreyberg II patients were younger, more frequently Jewish, and had higher educational/occupational levels (males) than Kreyberg I.
  • These demographic differences persisted after controlling for cigarette smoking.
  • A significant increase in Kreyberg II frequency over time was observed, with a decreasing Kreyberg I:Kreyberg II ratio in younger age groups.

Conclusions:

  • The observed increase in Kreyberg II lung cancer cases is a real phenomenon, not an artifact of diagnostic changes.
  • Demographic shifts suggest potential etiological factors influencing recent changes in lung cancer cell type distribution.
  • Further research into non-smoking related factors is warranted to explain these epidemiological trends.

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