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Updated: Aug 10, 2025

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

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Published on: March 13, 2018

Multiplex microdisk biosensor based on simultaneous intensity and phase detection.

Johannes Bläsi, Martina Gerken

|February 14, 2023

Summary

This study introduces a novel photonic crystal microdisk biosensor for multiplex biomarker detection. It combines intensity and phase measurements for enhanced precision medicine applications.

Area of Science:

Biomedical Engineering
Nanotechnology
Photonics

Background:

Precision medicine and advanced healthcare demand highly sensitive and reliable multiplex biosensing technologies.
Existing biosensors face challenges in achieving both high sensitivity and reliability for simultaneous detection of multiple biomarkers.

Purpose of the Study:

To develop and demonstrate a compact photonic crystal microdisk biosensor capable of simultaneous intensity and phase measurements for multiplex biomarker detection.
To leverage the advantages of both intensity and phase detection methods for improved biosensor performance.

Main Methods:

Utilized a photonic crystal microdisk resonator design for biosensing.
Implemented simultaneous intensity and phase measurement techniques.

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Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

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Last Updated: Aug 10, 2025

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

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Validated the biosensor performance through simulations and experimental measurements.

Main Results:

Demonstrated parallel measurement of intensity and phase shifts.
Successfully detected the binding of human alpha-thrombin and streptavidin.
Showcased the potential for high signal-to-noise ratios (phase) and increased reliability (intensity).

Conclusions:

The developed microdisk biosensor offers a promising platform for multiplex biomarker detection in future healthcare.
The combined intensity and phase measurement strategy enhances biosensor reliability and sensitivity.
This technology supports the advancement of precision medicine through advanced biosensing capabilities.