[Undifferentiated pancreatic carcinoma with osteoclast-like giant cells]

In the structure of malignant oncological diseases of the Russian population, pancreatic cancer (PCa) occupies the 10th place with a high mortality rate in case of late diagnosis, which is primarily due to the minimal clinical manifestations of this pathology and the absence of precancer as a potential substrate for screening. Undifferentiated pancreatic carcinoma with osteoclast-like giant cell (UC-OGC) is a rare histological variant of PCa with discussed bidirectional histogenesis (epithelial and mesenchymal), epithelial-mesenchymal transition in the tumor and variable prognosis depending on the predominant cellular component. A review of the literature reflecting debatable issues of origin, clinical and pathological characteristics and prognosis of UC-OGC, as well as a description of a clinical case is relevant due to the rare occurrence of this tumor in the routine work of pathologists and oncologists.