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Updated: Aug 10, 2025

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
Anisotropic 1 H STD-NMR Spectroscopy: Exploration of Enantiomer-Polypeptide Interactions in Chiral Oriented
Boris Gouilleux1, François-Marie Moussallieh1, Philippe Lesot1,2
1Université Paris-Saclay, UFR d'Orsay, RMN en Milieu Orienté, ICMMO, UMR CNRS 8182, Bât. 410, 15, rue du Doyen Georges Poitou, 91405, Orsay cedex, France.
Abstract:
The front cover artwork is provided by Dr. Philippe Lesot's group (NMR in Oriented Media, ICMMO, UMR CNRS 8182) at Université Paris-Saclay, France. The image shows four pieces of a puzzle: the magnet of an NMR spectrometer, the principle of the 1 H STD-NMR experiment and the 3D helical structure of the poly-γ-benzyl-L-glutamate polymer leading to a chiral liquid-crystalline phase that discriminates the enantiomers of a model chiral solute (1-phenethyl alcohol). Putting these pieces of the puzzle together allows us to identify the hydrogen sites of each enantiomer interacting with the polypeptide side chain. These new outcomes are a further step towards a global understanding of the chiral recognition that occurs in such media. Read the full text of the Research Article at 10.1002/cphc.202200508.
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