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May carriers at nanoscale improve the Endodontic's future?
Patrícia Diogo1, M Amparo F Faustino2, Paulo J Palma1
1Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal; Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal.
Advanced Drug Delivery Reviews
|February 14, 2023
Summary
This review explores nanocarriers (NCs) for antimicrobial applications in endodontics. While promising, research gaps and limitations prevent definitive conclusions on optimal NCs for effective endodontic antimicrobial outcomes.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Endodontics
Background:
- Nanocarriers (NCs) are versatile nanovehicles for delivering bioactive compounds like drugs and dyes.
- Antimicrobial applications of NCs are gaining traction in various medical fields.
Purpose of the Study:
- To review and understand the mechanisms of action of recently developed nanocarriers (NCs) for antimicrobial purposes.
- To highlight nineteen specific approaches utilizing NCs based on in vitro antimicrobial assay outcomes.
- To encourage the application of NCs in endodontic antimicrobial research by detailing their biochemical challenges.
Main Methods:
- Review of existing literature on nanocarriers with antimicrobial functions.
- Analysis of nineteen distinct approaches validated through in vitro antimicrobial assays.
- Identification and discussion of biochemical challenges associated with various NCs.
Main Results:
- Nine varieties of nanocarriers (NCs) and nineteen antimicrobial approaches are detailed.
- In vitro antimicrobial assay results are presented for each approach.
- Biochemical challenges inherent to the discussed NCs are underlined.
Conclusions:
- Methodological limitations and knowledge gaps currently prevent a definitive conclusion on the best NCs for endodontic antimicrobial applications.
- The emergent field of NCs in endodontics requires further pre-clinical and clinical trials.
- Significant room for improvement exists in optimizing NCs for efficient antimicrobial outcomes in endodontic studies.
