Heterocyclic Hemipiperazines: Water-Compatible Peptide-Derived Photoswitches
Peter Gödtel1, Jessica Starrett1, Zbigniew L Pianowski1,2
1Institute of Organic Chemistry, Karlsruhe Institute of Technology KIT, 76131, Karlsruhe, Germany.
Abstract:
Hemipiperazines are a recently discovered class of peptide-derived molecular photoswitches with high biocompatibility and therapeutic potential. Here, for the first time we describe photochromism of heterocyclic hemipiperazines. They demonstrate long thermal lifetimes, and enlarged band separation between photoisomers. Efficient photoisomerization occurs under aqueous conditions, although with a need for organic co-solvent. Bidirectional switching with visible light is observed for an extended aromatic system.
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