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Related Experiment Video

Updated: Aug 10, 2025

Formation of Dispersible Taohong Siwu Tablets

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Published on: February 3, 2023

Variation and Risk Analysis in Tablet Press Control for Continuous Manufacturing of Solid Dosage via Direct

Qinglin Su¹, Yasasvi Bommireddy², Marcial Gonzalez²

¹Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, US.

International Symposium on Process Systems Engineering

|February 15, 2023

Summary

This summary is machine-generated.

Process variations in continuous tablet manufacturing significantly impact product quality. A hierarchical control system effectively reduces these variations, enabling real-time release of solid dosage forms.

Keywords:

continuous manufacturing process control risk analysis tablet press

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Area of Science:

Pharmaceutical Manufacturing
Chemical Engineering
Process Control

Background:

Continuous manufacturing of solid dosage forms relies on rotary tablet presses.
Process variations in tablet presses challenge real-time release due to inconsistent product quality attributes like hardness and weight.

Purpose of the Study:

To investigate powder compressibility, system dynamics, and variation in a continuous tablet press.
To develop and evaluate a process control structure for reducing variations in pharmaceutical continuous manufacturing.

Main Methods:

Characterization of powder compressibility using a Natoli BLP-16 tablet press with an Acetaminophen blend.
Analysis of interacting effects of tableting parameters (dosing, speed, force) on die-filling and product quality.
Design and evaluation of a hierarchical three-level control system (built-in, PID, model predictive control).

Main Results:

Tablet compressibility was largely independent of tableting speed.
Dosing level, turret speed, feed-frame speed, and compression force significantly interacted to affect die-filling and quality attributes.
The proposed hierarchical control design effectively reduced process and product quality variations.

Conclusions:

Process control structure design is crucial for minimizing variations in continuous tablet manufacturing.
A hierarchical control approach can successfully manage process dynamics and ensure consistent product quality.
This study provides insights for real-time release strategies in pharmaceutical continuous manufacturing.