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Frailty in end stage renal disease: Current perspectives
Shankar Prasad Nagaraju1, Srinivas Vinayak Shenoy1, Ankur Gupta2
1Department of Nephrology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Nefrologia
|February 15, 2023
Summary
Frailty is common in end-stage renal disease (ESRD), indicating poor outcomes. This review covers frailty
Area of Science:
- Nephrology
- Geriatrics
- Internal Medicine
Background:
- Frailty is highly prevalent in end-stage renal disease (ESRD).
- Frailty worsens with chronic kidney disease (CKD) progression.
- Frailty is a significant predictor of adverse outcomes in ESRD patients.
Purpose of the Study:
- To review the significance of frailty in ESRD.
- To explore the multifactorial pathogenesis of frailty in ESRD.
- To discuss screening, prognostic implications, and management of frailty in ESRD.
Main Methods:
- Literature review of frailty in ESRD.
- Synthesis of current evidence on frailty assessment tools.
- Discussion of contributing factors like uremia and dialysis.
Main Results:
- Multiple tools exist for frailty assessment in ESRD.
- Uremia and dialysis-related factors contribute to frailty pathogenesis.
- Frailty has significant prognostic implications in ESRD.
Conclusions:
- Frailty is a critical issue in ESRD management.
- Early screening and tailored management strategies are essential.
- Understanding frailty's pathogenesis aids in developing interventions.
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