Hungarian PROMIS-29+2: psychometric properties and population reference values.

Area of Science:

• Health Outcomes Research
• Psychometrics
• Population Health

Background:

• Patient-Reported Outcomes Measurement Information System (PROMIS) measures are widely used for assessing health status.
• Validating PROMIS measures in different linguistic and cultural contexts is crucial for their global application.
• Hungary lacked specific population reference values for the PROMIS-29+2 profile measure.

Purpose of the Study:

• To evaluate the psychometric properties of the Hungarian version of the PROMIS-29+2 profile measure.
• To establish general population reference values for the Hungarian PROMIS-29+2.
• To assess the validity and reliability of the measure in a Hungarian adult sample.

Main Methods:

• A general adult population sample (n=1700) in Hungary completed the PROMIS-29+2 v2.1 via an online survey.
• Psychometric properties including floor/ceiling effects, internal consistency (McDonald's omega), convergent validity (with SF-36v1), unidimensionality, local independence, monotonicity, graded response model (GRM) fit, and differential item functioning (DIF) were assessed.
• Age- and gender-specific reference values were derived using US item calibrations.

Main Results:

• Most PROMIS-29+2 domains exhibited satisfactory psychometric properties, with high internal consistency (omega: 0.87-0.97) and strong correlations with SF-36 domains (r=│0.60│-│0.78│).
• The sleep disturbance domain showed significant item misfit and low discrimination, indicating substantial underperformance.
• Age-related trends showed increased physical function, pain interference, and social role difficulties with age, while anxiety, depression, fatigue, and cognitive function issues declined. Females reported more health problems than males across most domains.

Conclusions:

• The Hungarian PROMIS-29+2 generally demonstrates acceptable psychometric performance, supporting its use for health outcome assessment in Hungary.
• The sleep disturbance domain requires further investigation and potential revision due to identified psychometric limitations.
• Generated population reference values will aid in interpreting PROMIS-29+2 scores for diverse patient groups within Hungary.