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Related Experiment Video

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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

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Neuroimmune cardiovascular interfaces in atherosclerosis.

Sarajo K Mohanta^1,2, Changjun Yin^1,2,3, Christian Weber^1,2,4

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.

Frontiers in Cell and Developmental Biology

|February 16, 2023

Summary

The nervous, immune, and cardiovascular systems interact in complex tripartite networks. These neuroimmune cardiovascular interfaces (NICIs) offer a new framework for understanding tissue regulation and disease.

Keywords:

adventitia artery tertiary lymphoid organs atherosclerosis neuroimmune cardiovascular interface neuroimmunology neurovascular link

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Area of Science:

Physiology
Immunology
Neuroscience
Cardiovascular Science

Background:

The nervous, vascular, and immune systems regulate physiological and pathological tissue reactions.
Previous research focused on bipartite interactions, such as the neurovascular link and neuroimmunology.
These interactions are crucial for processes like blood-brain barrier formation, axon growth, angiogenesis, immune responses, and blood vessel integrity.

Purpose of the Study:

To propose a more inclusive approach to understanding the interplay between the nervous, immune, and cardiovascular systems.
To conceptualize and combine principles of the neurovascular link and neuroimmunology.
To introduce the concept of neuroimmune cardiovascular interfaces (NICIs) as tripartite interactions.

Main Methods:

Literature review and synthesis of existing research on neurovascular and neuroimmune interactions.
Conceptual framework development integrating nervous, immune, and cardiovascular system crosstalk.
Application of the framework to understand atherosclerosis.

Main Results:

Identified that the nervous, immune, and cardiovascular systems engage in complex crosstalk.
Proposed that these interactions are tripartite rather than bipartite.
Introduced the concept of neuroimmune cardiovascular interfaces (NICIs).

Conclusions:

NICIs represent a novel framework for understanding the integrated regulation of physiological and pathological tissue reactions.
This tripartite interaction model offers new insights into diseases like atherosclerosis.
Future research should explore the mechanisms and implications of NICIs in various biological contexts.