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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
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Targeted and responsive biomaterials in osteoarthritis
Jiadong Li1,2,3,4, Hao Zhang1,2, Yafei Han1,2
1Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Theranostics
|February 16, 2023
Summary
Biomaterials offer new hope for osteoarthritis (OA) treatment by improving drug delivery and targeting. Future strategies focus on multifunctional biomaterials for precision medicine in managing this degenerative joint disease.
Area of Science:
- Biomaterials Science
- Orthopedics
- Pharmacology
Background:
- Osteoarthritis (OA) is a degenerative joint disease marked by cartilage loss and inflammation.
- Joints' dense matrix and poor vascularity hinder effective drug delivery, leading to low bioavailability.
- An aging population necessitates safer and more effective OA therapies.
Purpose of the Study:
- To review current understanding of OA pathology and treatment challenges.
- To summarize advances in targeted and responsive biomaterials for OA.
- To provide perspectives on future OA therapeutic strategies.
Main Methods:
- Review of current literature on OA mechanisms and biomaterial applications.
- Analysis of targeted and responsive biomaterials for OA treatment.
- Discussion of clinical translation and biosafety challenges.
Main Results:
- Biomaterials show promise in enhancing drug targeting and prolonging action for OA.
- Targeted and responsive biomaterials offer potential for precision OA therapy.
- Review covers various biomaterial strategies and their efficacy.
Conclusions:
- Multifunctional biomaterials are crucial for future OA management.
- Tissue targeting and controlled release biomaterials align with precision medicine goals.
- Addressing clinical translation and biosafety is key for advanced OA therapies.
