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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Targeted and responsive biomaterials in osteoarthritis
Jiadong Li1,2,3,4, Hao Zhang1,2, Yafei Han1,2
1Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Abstract:
Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, involving multiple cellular dysfunctions and tissue lesions. The non-vascular environment and dense cartilage matrix in the joints tend to block drug penetration, resulting in low drug bioavailability. There is a desire to develop safer and more effective OA therapies to meet the challenges of an aging world population in the future. Biomaterials have achieved satisfactory results in improving drug targeting, prolonging the duration of action, and achieving precision therapy. This article reviews the current basic understanding of the pathological mechanisms and clinical treatment dilemmas of OA, summarizes and discusses the advances for different kinds of targeted and responsive biomaterials in OA, seeking to provide new perspectives for the treatment of OA. Subsequently, limitations and challenges in clinical translation and biosafety are analyzed to guide the development of future therapeutic strategies for OA. As the need for precision medicine rises over time, emerging multifunctional biomaterials based on tissue targeting and controlled release will become an irreplaceable part of OA management.
Insights
Biomaterials offer new hope for osteoarthritis (OA) treatment by improving drug delivery and targeting. Future strategies focus on multifunctional biomaterials for precision medicine in managing this degenerative joint disease.
Area of Science:
- Biomaterials Science
- Orthopedics
- Pharmacology
Background:
- Osteoarthritis (OA) is a degenerative joint disease marked by cartilage loss and inflammation.
- Joints' dense matrix and poor vascularity hinder effective drug delivery, leading to low bioavailability.
- An aging population necessitates safer and more effective OA therapies.
Purpose of the Study:
- To review current understanding of OA pathology and treatment challenges.
- To summarize advances in targeted and responsive biomaterials for OA.
- To provide perspectives on future OA therapeutic strategies.
Main Methods:
- Review of current literature on OA mechanisms and biomaterial applications.
- Analysis of targeted and responsive biomaterials for OA treatment.
- Discussion of clinical translation and biosafety challenges.
Main Results:
- Biomaterials show promise in enhancing drug targeting and prolonging action for OA.
- Targeted and responsive biomaterials offer potential for precision OA therapy.
- Review covers various biomaterial strategies and their efficacy.
Conclusions:
- Multifunctional biomaterials are crucial for future OA management.
- Tissue targeting and controlled release biomaterials align with precision medicine goals.
- Addressing clinical translation and biosafety is key for advanced OA therapies.
