Related Experiment Video
Updated: Aug 9, 2025

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
Has COVID-19 Changed Pediatric Acute Rhinosinusitis Epidemiology During the First 2 Pandemic Years?
Itai Hazan1, Oren Ziv2,3, Tal Marom2,3,4
1From the Joyce and Irvin Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba, Israel.
Insights
Pediatric acute rhinosinusitis (ARS) burden significantly decreased during the first two years of coronavirus-19 (COVID). This study found a substantial, threefold higher reduction in ARS compared to urinary tract infections (UTIs).
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- The coronavirus-19 (COVID) pandemic introduced significant societal changes, including lockdowns and altered public health behaviors.
- Understanding the impact of these changes on common pediatric infections like acute rhinosinusitis (ARS) is crucial for public health planning.
Purpose of the Study:
- To analyze national pediatric acute rhinosinusitis (ARS) burden fluctuations before and during the initial two years of the COVID-19 pandemic.
- To compare ARS trends with non-viral infections, such as urinary tract infections (UTIs), to assess the pandemic's specific impact.
Main Methods:
- A cross-sectional, population-based study utilized data from Israel's largest Health Maintenance Organization, covering three pre-COVID years and the first two COVID years.
- Pediatric ARS and UTI episodes were identified and categorized by age and presentation date.
- Incidence rate ratios (IRRs) were calculated comparing COVID years to pre-COVID averages, with seasonal variations analyzed.
Main Results:
- A substantial reduction in pediatric ARS episodes was observed during the COVID years (IRR 0.36), a decrease threefold greater than that seen in UTIs (IRR 0.79).
- The most significant decline in ARS burden occurred during the first year of the COVID-19 pandemic.
- While ARS episodes showed seasonal peaks in summer during the COVID period, the overall distribution was year-round.
Conclusions:
- The COVID-19 pandemic led to a significant decrease in the burden of pediatric acute rhinosinusitis.
- The findings highlight the profound impact of pandemic-related measures on the epidemiology of common childhood infections.
Objective:
To study national pediatric acute rhinosinusitis (ARS) burden fluctuations before and during the first 2 coronavirus-19 (COVID) years, characterized by alternating lockdown and relaxation periods, the introduction of COVID vaccines, and the emergence of nonalpha COVID variants.
Methods:
This was a cross-sectional, population-based study covering the 3 pre-COVID years and the first 2 COVID years from a big database of the largest Israeli Health Maintenance Organization. For comparison purposes, we explored ARS burden trends with those of urinary tract infection (UTI), which is unrelated to viral diseases. We identified children <15 years presenting with ARS and UTI episodes and categorized them according to their age and presentation date. The average ARS and UTI episodes of the 3 pre-COVID years were used to calculate the incidence rate ratios (IRRs) of the 2 COVID years, analyzed separately. Seasonal variations were explored.
Results:
We identified 44,483 ARS and 121,263 UTI episodes. There was a substantial reduction in ARS episodes during the COVID years (IRR 0.36, 95% CI: 0.24-0.56, P < 0.001). Although UTI episode rates also decreased during COVID (IRR 0.79, 95% CI: 0.72-0.86, P < 0.001), the reduction in ARS burden was 3-fold higher. The dominant pediatric ARS age group was between 5 and 15 years. The largest decrease in ARS burden was during the first COVID year. ARS episode distribution showed a seasonal fluctuation, with a peak during the summer months during the COVID years.
Conclusions:
Pediatric ARS burden decreased during the first 2 COVID years. Episode distribution was noted to be year-round.
More Related Videos
Related Concept Videos
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Tonsillitis II: Management
Upper Respiratory Drugs: First and Second-Generation Antihistamines
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.

