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Related Experiment Videos

Transient hyperphosphatasemia of infancy.

E Kerem1, J Urbach, R M Reifen

  • 1Department of Pediatrics, Bikur Holim Hospital, Jerusalem, Israel.

Israel Journal of Medical Sciences
|August 1, 1987
PubMed
Summary
This summary is machine-generated.

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Benign hyperphosphatasemia, characterized by very high serum alkaline phosphatase levels in young children, resolves spontaneously. This condition, originating from the liver or bone, aids in diagnosing elevated alkaline phosphatase.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Clinical Chemistry

Background:

  • Elevated serum alkaline phosphatase (ALP) levels in children can indicate various underlying conditions, necessitating careful differential diagnosis.
  • Idiopathic or benign hyperphosphatasemia is a rare condition characterized by significantly elevated ALP without apparent pathology.

Observation:

  • Four children aged 13-24 months presented with markedly elevated serum ALP levels.
  • No other clinical abnormalities or causative factors were identified in these children.
  • Isoenzyme studies indicated the liver and bone as primary sources of elevated ALP in affected children.

Findings:

  • Serum ALP levels normalized spontaneously in all four children within 5 to 20 weeks.
  • The elevated ALP levels were attributed to benign, transient hyperphosphatasemia.

Related Experiment Videos

  • Isoenzyme analysis localized the source of elevated ALP to the liver in one case and bone in two cases, with one undetermined.

    • Implications:

    • Recognizing benign hyperphosphatasemia is crucial for pediatricians to avoid unnecessary investigations and interventions.
    • This condition highlights the importance of considering transient, non-pathological causes of elevated serum ALP in pediatric patients.
    • Early identification of benign hyperphosphatasemia aids in accurate differential diagnosis and appropriate patient management.