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Related Experiment Video

Updated: Aug 9, 2025

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Ferrets: A powerful model of SARS-CoV-2.

Yan Zhao1,2, Chang-Le Wang1, Zhi-Yun Gao1,2

  • 1Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, Hebei 050017, China.

Zoological Research
|February 17, 2023
PubMed
Summary

Ferret models are vital for understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenicity and evaluating COVID-19 vaccines and therapeutics. These animals offer a suitable model for studying SARS-CoV-2 and its variants.

Keywords:
Angiotensin-converting enzyme 2 (ACE2) receptorAnimal modelsCOVID-19FerretSARS-CoV-2

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Area of Science:

  • * Virology
  • * Immunology
  • * Animal Models

Background:

  • * The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant health, social, and economic disruptions.
  • * Emerging SARS-CoV-2 variants present ongoing challenges, with limited understanding of their pathogenicity and a need for effective treatments.
  • * Current animal models for studying coronavirus disease 2019 (COVID-19) include mice, hamsters, ferrets, and non-human primates (NHPs).

Purpose of the Study:

  • * To review the development and application of SARS-CoV-2 ferret models in COVID-19 research.
  • * To highlight the utility of ferret models in investigating viral pathogenesis, therapeutic agents, and vaccine efficacy.
  • * To discuss the future role of ferret models in controlling the spread of SARS-CoV-2 and its variants.

Main Methods:

  • * Comprehensive literature review of studies utilizing SARS-CoV-2 ferret models.
  • * Analysis of research focusing on pathogenesis, antiviral therapies, and vaccine development in ferrets.
  • * Synthesis of findings to assess the suitability and impact of ferret models in COVID-19 research.

Main Results:

  • * Ferrets exhibit natural susceptibility to SARS-CoV-2 infection, mimicking aspects of human disease.
  • * SARS-CoV-2 ferret models have been instrumental in understanding viral spread, pathogenesis, and immune responses.
  • * These models have facilitated preclinical testing of various vaccines and antiviral drugs against SARS-CoV-2.

Conclusions:

  • * Ferret models are a valuable tool for advancing the understanding of SARS-CoV-2 pathogenesis and transmission.
  • * The application of ferret models is crucial for the effective preclinical evaluation of COVID-19 countermeasures, including vaccines and therapeutics.
  • * Continued use and development of SARS-CoV-2 ferret models will aid in combating the COVID-19 pandemic and future viral threats.