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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

451
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Related Experiment Video

Updated: Aug 9, 2025

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

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[Delayed graft function : an ongoing clinical challenge].

Pauline Erpicum1,2, Tiago Pinto Coelho2, Catherine Bonvoisin1

  • 1Service de Néphrologie, Dialyse et Transplantation, CHU Liège, Belgique.

Revue Medicale De Liege
|February 17, 2023
PubMed
Summary
This summary is machine-generated.

Delayed Graft Function (DGF) impacts kidney transplant survival. Strategies like mesenchymal stromal cell therapy during perfusion show promise for mitigating ischemic damage and improving graft outcomes.

Keywords:
Delayed graft functionMesenchymal stromal cellsRenal transplantation

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Area of Science:

  • Nephrology and Transplant Surgery
  • Immunology and Cellular Therapy

Context:

  • Delayed Graft Function (DGF) is a common complication after kidney transplantation, necessitating dialysis within the first week.
  • DGF arises primarily from ischemia/reperfusion injury during the transplant process.
  • DGF is linked to increased acute rejection risk and reduced long-term graft survival.

Purpose:

  • To define Delayed Graft Function (DGF) and identify its predictive factors.
  • To review the impact of DGF on graft outcomes.
  • To discuss current and emerging strategies for DGF prevention, including cellular therapy.

Summary:

  • This review explores definitions and predictive factors of DGF in kidney transplantation.
  • It highlights the association between DGF, acute rejection, and diminished graft survival.
  • Emerging strategies, such as mesenchymal stromal cell (MSC) therapy during machine perfusion, are discussed for mitigating ischemic damage.

Impact:

  • Understanding DGF and its risk factors can guide clinical management and improve patient counseling.
  • Investigating novel therapies like MSCs offers potential to enhance graft quality and long-term transplant success.
  • This review provides insights into current prevention strategies and future directions in managing DGF.