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A new pyrrole-amidine antibiotic TAN-868 A
M Takizawa1, S Tsubotani, S Tanida
1Applied Microbiology Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
The Journal of Antibiotics
|September 1, 1987
Abstract:
A new pyrrole-amidine antibiotic TAN-868 A was isolated from the culture broth of Streptomyces idiomorphus sp. nov. Its chemical structure was determined by spectroscopic analyses and degradation studies to be 4-[(2S,4R)-4-hydroxy-5-iminoprolyl]amino- N-(2-amidinoethenyl)-2-pyrrolecarboxamide. The antibiotic is active against bacteria, fungi and a protozoan, and has cytotoxic activity against murine tumor cells. DNA thermal denaturation studies suggest that TAN-868 A preferentially interacts with AT rich regions of double-stranded DNA.