Related Experiment Video
Updated: Aug 9, 2025
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Childhood Chronic Idiopathic Uveitis in a Multicentre International Cohort
Ilaria Maccora1,2, Catherine Guly3, Cinzia de Libero4
1Rheumatology Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Insights
Idiopathic uveitis in children often presents with vision impairment. While most children experience vision improvement over time, some may still have lasting visual deficits.
Area of Science:
- Ophthalmology
- Pediatric Medicine
- Inflammatory Eye Diseases
Background:
- Idiopathic uveitis constitutes approximately 50% of non-infectious uveitis cases.
- Clinical characteristics of idiopathic uveitis in pediatric populations are not well-documented.
Purpose of the Study:
- To delineate the demographic and clinical features of children diagnosed with idiopathic non-infectious uveitis (iNIU).
- To evaluate the visual outcomes for children with iNIU over a 3-year follow-up period.
Main Methods:
- A multicentric retrospective study was conducted.
- Data collected included patient demographics, clinical presentation, and visual acuity at diagnosis and 3-year follow-up.
Main Results:
- The study included 126 children (61% female) with a median age of 9.3 years at diagnosis.
- Uveitis was bilateral in 106 patients and anterior in 68.
- At presentation, 24.4% had impaired visual acuity and 15.1% had blindness in the worse eye; however, significant visual improvement was observed by 3 years (p < .001).
Conclusions:
- Children with idiopathic uveitis frequently present with visual impairment.
- While most achieve significant visual recovery, approximately 1 in 6 children experience persistent vision impairment or blindness in their worse eye at 3 years.
Importance:
Idiopathic uveitis makes up around 50% of non-infectious uveitis but the clinical characteristics in children are poorly understood.
Objective:
To report the demographic, clinical characteristics, and outcomes of children with idiopathic non-infectious uveitis (iNIU) in a multicentric retrospective study.
Results:
There were 126 (61 female) children with iNIU. The median age at diagnosis was 9.3 years (3-16 years) . Uveitis was bilateral in 106 patients and anterior in 68.At onset,impaired visual acuity and blindness in the worse eye were reported, in 24.4% and 15.1% patients but at 3 years of follow-up, there was a significant improvement in visual acuity (mean 0.11 SD ±0.50 vs 0.42 SD ± 0.59 p < .001).
Conclusions And Relevance:
There is a high rate of visual impairment at presentation in children with idiopathic uveitis. The majority of patients have a significant improvement in vision, but 1 in 6 had impaired vision or blindness in their worse eye at 3 years.
Related Concept Videos
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:24Chronic Kidney Disease II: Clinical Manifestations
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:08Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are: