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Role of autophagy and its regulation by noncoding RNAs in ovarian cancer

Cong Feng1,2, Xingxing Yuan2,3

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, P.R. China.

Experimental Biology and Medicine (Maywood, N.J.)
|February 21, 2023
PubMed

Insights

Autophagy, a cellular process, is crucial in ovarian cancer (OC) progression and treatment. Noncoding RNAs (ncRNAs) regulate autophagy in OC, offering potential therapeutic targets.

Area of Science:

  • Cell Biology
  • Molecular Oncology

Background:

  • Autophagy is a fundamental cellular process for degrading damaged components, essential for maintaining homeostasis.
  • Autophagy plays a significant role in the development, metastasis, and chemoresistance of various cancers, including ovarian cancer (OC).

Purpose of the Study:

  • To review the role of autophagy in ovarian cancer (OC) progression and treatment.
  • To discuss the regulatory functions of noncoding RNAs (ncRNAs) in modulating autophagy within OC cells.

Main Methods:

  • Literature review of studies investigating autophagy and ncRNAs in ovarian cancer.
  • Synthesis of current research on ncRNA-mediated regulation of autophagosome formation and its impact on OC.

Main Results:

  • Autophagy is implicated in OC tumorigenesis, metastasis, and chemoresistance.
  • ncRNAs, including microRNAs, long noncoding RNAs, and circular RNAs, are key regulators of autophagy in OC cells.
  • Modulation of autophagosome formation by ncRNAs influences OC progression and chemoresistance.

Conclusions:

  • Understanding autophagy's role in OC is vital for improving treatment and prognosis.
  • ncRNA-mediated autophagy presents promising avenues for developing novel therapeutic intervention strategies for ovarian cancer.
Keywords:
Ovarian cancerautophagychemoresistancenoncoding RNAprogressiontumorigenesis

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