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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Aug 9, 2025

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
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Glyphosate exposure and preterm birth: A nested case-control pilot study.

Meghana Varde1, Roy R Gerona2, Roger B Newman3

  • 1Department of Global and Community Health, George Mason University, 4400 University Dr., MS 5B7, Fairfax, VA, 22030, USA.

Reproductive Toxicology (Elmsford, N.Y.)
|February 21, 2023
PubMed
Summary
This summary is machine-generated.

This pilot study found no direct link between maternal glyphosate exposure and preterm birth (PTB). However, potential racial disparities in glyphosate levels warrant further investigation in diverse populations.

Keywords:
ExposureGlyphosatePreterm birthRacial disparity

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Area of Science:

  • Environmental Health
  • Reproductive Epidemiology
  • Toxicology

Background:

  • Preterm birth (PTB) poses significant risks to infant mortality and long-term health.
  • Glyphosate, a widely used herbicide, has been investigated for potential associations with adverse birth outcomes.
  • Previous studies on glyphosate and PTB have yielded inconsistent results, particularly in diverse populations.

Purpose of the Study:

  • To conduct a pilot study investigating the association between maternal urinary glyphosate levels and preterm birth in a racially diverse population.
  • To inform the design of a larger, more definitive study on glyphosate exposure and adverse birth outcomes.
  • To explore potential racial disparities in glyphosate exposure levels.

Main Methods:

  • A case-control pilot study involving 26 women with PTB (cases) and 26 women with term births (controls).
  • Urine samples were collected from participants in Charleston, South Carolina.
  • Statistical analyses included binomial logistic regression for PTB association and multinomial regression for racial disparities in glyphosate levels.

Main Results:

  • No significant association was found between maternal urinary glyphosate levels and the odds of preterm birth (OR = 1.06, 95% CI: 0.61, 1.86).
  • Preliminary findings suggested potential racial disparities, with Black women showing higher odds of "high" glyphosate levels compared to white women, though confidence intervals were wide and included the null.
  • Effect estimates for racial disparities were imprecise, indicating a need for larger sample sizes.

Conclusions:

  • This pilot study did not establish a direct link between glyphosate exposure and preterm birth.
  • Potential racial disparities in glyphosate exposure warrant further investigation in larger, more diverse cohorts.
  • Future research should incorporate longitudinal urinary glyphosate measurements, detailed dietary assessments, and identify specific exposure sources to confirm findings.