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Bilateral primary angiosarcoma of the breast: a case report
Yuka Ooe1,2, Hirofumi Terakawa3,4, Hiroko Kawashima4
1Department of Breast Surgery, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa, Japan. y.ooe0003@gmail.com.
Journal of Medical Case Reports
|February 21, 2023
Summary
Primary breast angiosarcoma is rare and aggressive. This case highlights the challenges in treating this malignancy, emphasizing the need for multimodal approaches due to poor prognosis and high recurrence rates.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Primary breast angiosarcoma is an exceptionally rare malignancy, comprising only 0.05% of all breast tumors.
- This cancer exhibits high malignant potential and is associated with a poor prognosis, complicated by a lack of established treatment protocols.
Observation:
- A case of bilateral primary angiosarcoma of the breast in a 30-year-old breastfeeding woman is presented.
- The patient experienced local recurrence with liver metastases despite undergoing surgery, radiation therapy, chemotherapy, and hepatic arterial infusion chemotherapy.
Findings:
- Treatment interventions including radiation, chemotherapy, and hepatic arterial infusion chemotherapy proved ineffective.
- The patient required multiple arterial embolization procedures to manage intratumoral bleeding and rupture of liver metastases.
Implications:
- Angiosarcoma is characterized by a high propensity for local recurrence and distant metastasis, leading to a generally poor prognosis.
- While evidence for radiotherapy and chemotherapy is limited, multimodality treatment strategies are crucial for managing the high malignancy and rapid progression of breast angiosarcoma.
