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Related Experiment Videos

Cutaneous lymphosarcoma with abnormal chromosomes in a dog.

D E Swayne1, K Michalski, D McCaw

  • 1Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia.

Journal of Comparative Pathology
|September 1, 1987
PubMed
Summary

A dog diagnosed with poorly differentiated cutaneous lymphosarcoma showed delayed, multicentric spread. Its tumor cells had abnormal chromosome numbers, differing from canine transmissible venereal tumors.

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Area of Science:

  • Veterinary Oncology
  • Canine Pathology
  • Cytogenetics

Background:

  • Cutaneous lymphosarcoma is a cancer affecting a dog's skin.
  • Understanding its spread and cellular characteristics is crucial for diagnosis.

Observation:

  • A dog presented with poorly differentiated cutaneous lymphosarcoma.
  • The tumor exhibited delayed multicentric anatomical distribution.
  • Neoplastic cells displayed chromosome numbers of 58 or 67.

Findings:

  • Cells with 58 chromosomes lacked a specific subtelocentric marker.
  • This marker is present in canine transmissible venereal tumor cells with 58 chromosomes.
  • The cytogenetic findings suggest a distinction from canine transmissible venereal tumor.

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Implications:

  • These findings aid in differentiating cutaneous lymphosarcoma from other canine neoplasms.
  • Cytogenetic analysis can be a valuable tool in veterinary cancer diagnosis.
  • Further research into the specific markers of canine lymphosarcoma is warranted.