Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

426
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
426
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

535
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
535
Association Areas of the Cortex01:21

Association Areas of the Cortex

5.7K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.7K
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

1.7K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.7K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

923
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
923
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

3.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural language processing captures memory content associated with shared neural patterns at encoding and retrieval.

Communications psychology·2026
Same author

A subject-specific reversible folding model reveals geometry-driven white-matter organization.

bioRxiv : the preprint server for biology·2025
Same author

Mapping hippocampal-cerebellar functional connectivity across the human adult lifespan.

Communications biology·2025
Same author

Image-Based Identification and Localisation of Changes in Intraoperative Brain Tumour Resection.

Journal of imaging informatics in medicine·2025
Same author

Guess quality moderates how semantic relatedness influences the pretesting effect.

Journal of experimental psychology. Learning, memory, and cognition·2025
Same author

Anticipatory eye gaze as a marker of memory.

Communications psychology·2025

Related Experiment Video

Updated: Aug 9, 2025

A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat
08:37

A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat

Published on: April 24, 2009

11.9K

A role for the fornix in temporal sequence memory.

Marie-Lucie Read1, Katja Umla-Runge2, Andrew D Lawrence1

  • 1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.

The European Journal of Neuroscience
|February 22, 2023
PubMed
Summary

The fornix, a key hippocampal pathway, shows microstructural complexity linked to better sequence memory. This suggests the fornix aids in remembering items within a temporal context.

Keywords:
diffusion MRIepisodic memoryfornixhippocampussequencetime

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.7K
Place and Response Learning in the Open-field Tower Maze
08:31

Place and Response Learning in the Open-field Tower Maze

Published on: October 28, 2015

10.5K

Related Experiment Videos

Last Updated: Aug 9, 2025

A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat
08:37

A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat

Published on: April 24, 2009

11.9K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.7K
Place and Response Learning in the Open-field Tower Maze
08:31

Place and Response Learning in the Open-field Tower Maze

Published on: October 28, 2015

10.5K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neuroimaging

Background:

  • The hippocampus is crucial for sequence learning, binding items based on temporal context.
  • The fornix is a major white matter pathway connecting the hippocampus to other brain regions.

Purpose of the Study:

  • To investigate if individual differences in fornix microstructure predict sequence memory performance.
  • To compare fornix microstructure with other white matter tracts not primarily linked to the hippocampus.

Main Methods:

  • Diffusion MRI (multi-shell) with Free-Water Elimination Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging was used.
  • Tractography was performed on 51 healthy adults who completed a sequence memory task.
  • Principal components analysis created indices for axonal packing/myelin (PC1) and microstructural complexity (PC2).

Main Results:

  • A significant positive correlation was found between fornix microstructural complexity (PC2) and implicit sequence memory.
  • No significant relationship was observed between sequence memory and microstructure of the Parahippocampal Cingulum bundle (PHC) or Inferior Longitudinal Fasciculus (ILF).

Conclusions:

  • Forntix microstructural complexity is important for sequence memory, highlighting its role in temporal context.
  • The fornix may mediate communication within an extended hippocampal system for memory.
  • This study underscores the fornix's specific contribution to memory beyond other medial temporal lobe pathways.