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Published on: March 25, 2016
Loss of CD34 Expression within an Interstitial Dermal Lymphoid Cell Infiltrate Is a Helpful Clue to the Diagnosis of
Maged Daruish1, Anoud Zidan1, Danielle T Greenblatt2
1Department of Dermatopathology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
Abstract:
A dermal interstitial lymphocytic infiltrate may represent a diagnostic challenge, particularly if the clinical history is not provided. We present three cases within the histological spectrum of morphea in which the immunohistochemical marker CD34 was helpful in confirming the diagnosis.
Insights
Diagnosing morphea can be difficult with lymphocytic infiltrates. Immunohistochemistry using CD34 aids in confirming morphea diagnosis when clinical history is absent.
Area of Science:
- Dermatopathology
- Immunohistochemistry
- Connective Tissue Diseases
Background:
- Dermal interstitial lymphocytic infiltrates can mimic other conditions.
- Morphea diagnosis is challenging without clinical context.
- Immunohistochemistry plays a crucial role in differentiating skin lesions.
