Bridging Health Disparities: a Genomics and Transcriptomics Analysis by Race in Prostate Cancer
Kristi Y Lee1, Erica L Beatson1, Seth M Steinberg2
1Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Journal of Racial and Ethnic Health Disparities
|February 22, 2023
Summary
Racial disparities in prostate cancer exist, with Black men experiencing higher incidence and mortality than Asian men. This study explores genomic differences between these groups to understand these opposing trends.
Area of Science:
- Oncology
- Genomics
- Health Disparities
Background:
- Prostate cancer incidence and mortality rates vary significantly by race, with Black men disproportionately affected and Asian men showing the opposite trend.
- Understanding the genomic underpinnings of these disparities is crucial for addressing health inequities.
Purpose of the Study:
- To investigate race-based genomic differences in prostate cancer.
- To identify specific genes and pathways associated with varying cancer outcomes in Black versus Asian men.
Main Methods:
- Utilized the GENIE database (v11, Jan 2022) for race genomics analysis, examining mutation and copy number frequencies in primary and metastatic tumors.
- Conducted ancestry analysis and identified differentially expressed genes in the TCGA race cohort.
Main Results:
- Identified pathway-oriented genetic mutation frequencies that differ by race.
- Discovered candidate gene transcripts with differential expression between Black and Asian men.
Conclusions:
- Race-specific genomic profiles contribute to disparities in prostate cancer.
- Findings provide a foundation for targeted research into the genetic basis of prostate cancer health inequities.
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