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Updated: Aug 9, 2025

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Nevus Sebaceous with Multiple Basal Cell Carcinomas and Extracutaneous Abnormalities: Genetic Origin or Coincidence?
Kinga Tyczyńska, Piotr K Krajewski, Iwona Chlebicka
1Professor Jacek C Szepietowski, MD, PhD, Department of Dermatology, Venereology and Allergology Wroclaw Medical University, Wroclaw, Poland; jacek.szepietowski@umw.edu.pl.
Abstract:
The association of cutaneous and extracutaneous abnormalities is a common phenomenon, widely described in a variety of genetic syndromes. Nevertheless, yet undescribed syndromic combinations may still exist. Herein we present a case report of a patient who was admitted to the Dermatology Department due to multiple basal cell carcinomas arising from nevus sebaceous. In addition to the cutaneous malignancies, the patient presented with palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar abnormalities, uterine myoma, an ovarian cyst, and highly dysplastic colon adenoma. Such a combination of multiple disorders may indicate a genetic origin of the diseases.
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