Meatal Intraurethral Warts Successfully Treated with 5-fluorouracil Cream

Area of Science:

• Urology
• Dermatology
• Infectious Disease

Background:

• Condyloma acuminatum (genital warts) rarely affects the urethra, typically the distal portion.
• Various treatments exist for urethral condylomas, including laser, electrosurgery, cryotherapy, and topical agents.
• Laser therapy is often considered the primary treatment for intraurethral condylomata.

Observation:

• A 25-year-old male presented with meatal intraurethral warts.
• The patient underwent multiple unsuccessful treatment attempts.
• Previous treatments included laser therapy, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid.

Findings:

• Topical 5-fluorouracil (5-FU) cream was administered to the patient.
• Successful resolution of the meatal intraurethral warts was achieved with 5-FU therapy.

Implications:

• This case highlights 5-FU as a potential effective treatment for recalcitrant urethral condylomas.
• It suggests considering 5-FU for cases resistant to standard therapies.
• Further research may explore 5-FU's role in managing intraurethral warts.