Hydrophobic modified agar: Structural characterization and application in encapsulation and release of curcumin

In this study, three kinds of anhydrides with different structures were introduced into agar molecules to study the effects of varying degrees of substitution (DS) and anhydride structures on the physicochemical properties and curcumin (CUR) loading capacity. Increasing the carbon chain length and saturation of the anhydride affects the hydrophobic interaction and hydrogen bonding of the esterified agar, thereby changing the stable structure of the agar. Although the gel performance declined, the hydrophilic carboxyl group and the loose porous structure provide more binding sites for the adsorption of water molecules, hence providing excellent water retention (1700 %). Next, CUR was used as a hydrophobic active ingredient to study agar microspheres' drug encapsulation and in vitro release ability. Results showed that the excellent swelling and hydrophobic structure of esterified agar could promote the encapsulation of CUR (70.3 %). The release process is controlled by pH, and the release of CUR under weak alkaline conditions is significant, which can be explained by the pore structure, swelling characteristics, and carboxyl binding of agar. Therefore, this study shows the application potential of hydrogel microspheres in loading hydrophobic active ingredients and sustained release and provides the possibility for the application of agar in drug delivery systems.