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Microbiome of the Eye

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The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

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Eosinophilic Keratoconjunctivitis in Cats.

Amber Labelle¹, Philippe Labelle²

¹Bright Light Veterinary Eye Care, Ottawa, Ontario, Canada.

The Veterinary Clinics of North America. Small Animal Practice

|February 22, 2023

Summary

Eosinophilic keratitis in cats involves conjunctivitis and corneal plaques. Diagnosis relies on identifying eosinophils via cytology, with immunosuppressives as the primary treatment for this feline eye disease.

Keywords:

Cat Conjunctivitis Cornea Eosinophil Eosinophilic Feline Keratitis Keratoconjunctivitis

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Published on: August 4, 2022

Area of Science:

Ophthalmology
Veterinary Medicine
Feline Diseases

Background:

Eosinophilic keratitis (EK) is a feline ocular surface disease.
Characterized by conjunctivitis, raised plaques on cornea/conjunctiva, vascularization, and pain.
Eosinophilic conjunctivitis is a variant without corneal involvement.

Purpose of the Study:

To summarize the key aspects of feline eosinophilic keratitis.
To highlight diagnostic methods and therapeutic strategies.
To note the unclear role of feline herpesvirus-1 in pathogenesis.

Main Methods:

Cytological examination of corneal samples is the diagnostic method of choice.
Identification of eosinophils confirms the diagnosis.
Concurrent presence of other inflammatory cells (lymphocytes, mast cells, neutrophils) is common.

Main Results:

Cytology is effective in diagnosing eosinophilic keratitis.
Eosinophils are the key diagnostic cells, though not always exclusive.
Immunosuppressive therapy is the standard treatment approach.

Conclusions:

Eosinophilic keratitis is diagnosed via cytology, identifying eosinophils.
Immunosuppressives are the mainstay of treatment for feline EK.
The pathogenesis, including the role of feline herpesvirus-1, requires further investigation.