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The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
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Nuclear envelope budding and its cellular functions.

Katharina S Keuenhof1, Verena Kohler2,3, Filomena Broeskamp1

  • 1Department for Chemistry and Molecular biology, University of Gothenburg, Sweden.

Nucleus (Austin, Tex.)
|February 23, 2023
PubMed
Summary
This summary is machine-generated.

Nuclear envelope budding (NEB) may offer a physiological transport route beyond the nuclear pore complex (NPC). This process, similar to viral egress, could move RNA granules and proteins in healthy cells.

Keywords:
Nuclear importnuclear envelope buddingnuclear export

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Virology

Background:

  • The nuclear pore complex (NPC) is the primary pathway for nucleo-cytoplasmic transport in healthy cells.
  • Viruses utilize nuclear egress for transport across the nuclear envelope.
  • Emerging evidence suggests non-viral egress-like mechanisms in physiological conditions.

Purpose of the Study:

  • To review the known physiological roles of nuclear envelope budding (NEB).
  • To explore NEB as an alternative transport mechanism in healthy cells.
  • To identify unanswered questions regarding NEB.

Main Methods:

  • Literature review and synthesis of existing research on NEB.
  • Analysis of observations suggesting NEB in cellular processes.
  • Comparison of NEB with viral nuclear egress pathways.

Main Results:

  • Nuclear envelope budding (NEB) is proposed as a mechanism for transporting RNA granules, aggregated proteins, and other molecules.
  • NEB may represent a transient, physiological pathway in healthy cells, distinct from NPC-mediated transport.
  • Observations suggest NEB shares similarities with viral egress mechanisms.

Conclusions:

  • Nuclear envelope budding (NEB) is an intrinsic cellular feature with potential roles in physiological transport.
  • Further research is needed to fully understand the mechanisms and implications of NEB.
  • NEB presents a novel perspective on nucleo-cytoplasmic transport beyond the NPC.