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A bibliometric analysis of apoptosis in glaucoma
Jia-Heng Zhang1,2, Mei-Juan Wang3, Ya-Ting Tan1,4
1Center for Medical Research, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Frontiers in Neuroscience
|February 23, 2023
Summary
This study analyzes global trends in apoptosis research for glaucoma, a leading cause of irreversible blindness. Findings reveal an increasing publication trend and highlight key contributors, paving the way for advanced treatments for retinal ganglion cell death.
Area of Science:
- Ophthalmology
- Cell Biology
- Neuroscience
Background:
- Glaucoma is a leading cause of irreversible blindness, characterized by retinal ganglion cell (RGC) death and optic nerve degeneration.
- Apoptosis is identified as the primary mechanism driving RGC loss in glaucoma.
- Existing research has explored apoptosis mechanisms and therapeutic strategies, but global trends remain underexplored.
Purpose of the Study:
- To elucidate the global trends and research hotspots in apoptosis related to glaucoma.
- To provide a comprehensive overview of the scientific landscape concerning apoptosis in glaucoma.
- To identify leading institutions and countries in this research field.
Main Methods:
- Bibliometric analysis of publications from the Web of Science Core Collection (1999-2022).
- Utilized VOSviewer and CiteSpace software for visual and statistical analysis.
- Included articles and reviews published in English.
Main Results:
- A consistent increasing trend in publications on apoptosis in glaucoma was observed over time.
- The United States and China are leading in the number of publications and citations in this field.
- Emerging research is uncovering key regulatory mechanisms of RGC apoptosis, promising precise treatment strategies.
Conclusions:
- This research enhances understanding of apoptosis's role in glaucoma pathogenesis.
- Findings offer guidance for future basic research and clinical treatment strategies for glaucoma.
- The study highlights the growing momentum and key players in glaucoma apoptosis research.
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