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Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
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FcγRI FG-loop functions as a pH sensitive switch for IgG binding and release

Jinghua Lu1, Matthew Spencer1, Zhongcheng Zou1

  • 1Structural Immunology Section, Lab of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.

Frontiers in Immunology
|February 23, 2023
PubMed
Summary

The Fc gamma receptor I (FcγRI) uses its FG-loop as a pH-sensing switch to control binding to IgG antibodies. This mechanism is crucial for immune complex uptake and release, impacting therapeutic antibody engineering.

Keywords:
Fc-glycan recognitionantibody recognitionhuman FcγRIlive cell tracking of FcγRI-antibody endocytosispH sensitive bindingreceptor FG-loop

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