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[Precision medicine in the treatment of pediatric cancers]

Khalil Ben Hassine1, Francesco Ceppi2, Frederic Baleydier1,3

  • 1Plateforme de recherche CANSEARCH en oncologie et hématologie pédiatrique, Faculté de médecine, Département de la femme, de l'enfant et de l'adolescent, Université de Genève, Centre médical universitaire, 1206 Genève.

Revue Medicale Suisse
|February 23, 2023
PubMed

Insights

Precision medicine offers improved, less toxic treatments for pediatric cancers by targeting specific tumor cells and personalizing chemotherapy. This approach aims to overcome challenges in treating aggressive childhood cancers and reduce treatment side effects.

Area of Science:

  • Pediatric Oncology
  • Cancer Therapeutics
  • Molecular Oncology

Background:

  • Pediatric cancer cure rates have improved, but challenges persist, particularly in managing poor-prognosis diseases.
  • Intensified chemotherapies increase cure rates but also elevate risks of severe acute and chronic toxicities.
  • Current treatments for pediatric cancers face limitations in efficacy and toxicity profiles.

Approach:

  • Reviewing precision medicine strategies for pediatric cancers.
  • Evaluating therapies targeting tumor cells and inhibiting oncogenic molecular aberrations.
  • Exploring pharmacogenetics and precision dosing for personalized chemotherapy.

Key Points:

  • Targeted therapies and molecularly-driven treatments offer enhanced efficacy and reduced toxicity.
  • Pharmacogenetics and precision dosing can optimize chemotherapy effectiveness and safety.
  • Precision medicine strategies are crucial for advancing pediatric cancer care.

Conclusions:

  • Precision medicine represents a paradigm shift in treating pediatric cancers.
  • Personalized approaches hold significant promise for improving outcomes and minimizing side effects in children with cancer.
  • Continued clinical evaluation of precision medicine strategies is essential for pediatric oncology.

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