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Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering.

Qiaoyun Liu1, Changjiang Liu1, Weixing Wang1

  • 1Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Frontiers in Bioengineering and Biotechnology
|February 23, 2023
PubMed
Summary

New strontium magnesium phosphate cements (SMPCs) show enhanced biological activity and promote new bone formation for bone tissue engineering. This facile precursor method yields highly biocompatible and mechanically strong cements.

Keywords:
bioinspiredbiological activitybone tissue engineeringprecursor methodstrontium magnesium phosphate

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Area of Science:

  • Biomaterials Science
  • Biomineralization
  • Tissue Engineering

Background:

  • Bone tissue engineering requires advanced biomaterials with excellent biocompatibility and osteoconductive properties.
  • Current bone cements often face limitations in degradation rates and biological stimulation.
  • Developing novel cements with enhanced performance is crucial for regenerative medicine.

Purpose of the Study:

  • To develop bioinspired strontium magnesium phosphate cements (SMPCs) using an efficient and environmentally friendly precursor method.
  • To evaluate the physicochemical properties, biocompatibility, and in vitro biological responses of the novel SMPCs.
  • To investigate the potential of SMPCs for bone tissue engineering applications.

Main Methods:

  • A facile, high-yielding precursor method was employed to synthesize bioinspired strontium magnesium phosphate cements.
  • Physicochemical characterization included assessment of particle distribution and mechanical strength.
  • In vitro studies evaluated bone marrow stromal cell responses, including viability, osteogenic differentiation, and alkaline phosphatase activity.

Main Results:

  • The new precursor method achieved a high yield (98.5%) and produced SMPCs with uniform particle distribution and excellent mechanical strength.
  • Strontium-substituted SMPC (SMPC-2) exhibited a higher degradation rate and enhanced biological activity compared to magnesium phosphate cements.
  • SMPC-2 promoted cell proliferation, mineralized calcium deposition, and new bone formation, indicating superior osteoconductivity.

Conclusions:

  • The developed precursor method is feasible for generating high-quality bioinspired strontium magnesium phosphate cements.
  • SMPC-2 demonstrates significant potential as a highly effective and biologically compatible material for bone tissue engineering.
  • The synergistic release of strontium and magnesium ions from SMPC-2 creates an optimal environment for bone regeneration.