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Association between androgen receptor gene alteration and osteoporosis in Chinese Han elderly men

Xin Huang1,2,3, Zhengdong Zhang1,3, Liangxuan Zou1,2,3

  • 1Collaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Sichuan, China.

Peerj
|February 23, 2023
PubMed

Insights

Androgen receptor LL genotype and high total cholesterol are potential risk factors for osteoporosis in Chinese Han men. This study provides insights for identifying individuals susceptible to osteoporosis.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Genetics

Background:

  • Osteoporosis is a significant public health concern, particularly in aging populations.
  • The role of metabolic factors and genetic variations in osteoporosis pathogenesis requires further elucidation.
  • Understanding these factors can aid in developing targeted screening strategies.

Purpose of the Study:

  • To investigate the association between blood glucose, blood lipids, and androgen receptor gene (CAG)n polymorphism with osteoporosis in Chinese Han men.
  • To identify potential risk factors for osteoporosis in this demographic.
  • To provide a theoretical basis for osteoporosis screening.

Main Methods:

  • A case-control study involving 80 Chinese Han men (40 with osteoporosis, 40 controls).
  • Bone mineral density was measured using dual-energy X-ray absorptiometry.
  • Androgen receptor gene (CAG)n polymorphism was analyzed using the STR method; blood glucose, blood lipids, and other biochemical markers were assessed.

Main Results:

  • Significant differences were observed in average blood glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, and androgen receptor gene (CAG)n genotype frequency between osteoporosis and control groups (P < 0.05).
  • Multivariate logistic regression identified total cholesterol and androgen receptor gene (CAG)n genotype frequency as significant factors (P < 0.05).
  • No significant differences were found in age, calcium, phosphorus, alkaline phosphatase, and glycosylated hemoglobin.

Conclusions:

  • The LL genotype of the androgen receptor gene and elevated total cholesterol levels are identified as potential risk factors for osteoporosis in older Chinese Han men.
  • These findings contribute to understanding the multifactorial nature of osteoporosis.
  • The study highlights the importance of considering genetic predisposition and lipid profiles in osteoporosis risk assessment.
Abstract

Keywords:
Androgen receptor gene alterationBlood glucoseBlood lipidsChinese Han older menOsteoporosis

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