Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

670
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
670
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

602
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
602
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

514
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
514

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Fructus lycii</i> mitigates oxidative stress in dry age-related macular degeneration models <i>via</i> Nrf2/ARE pathway.

International journal of ophthalmology·2026
Same author

FGFR1-ETV1-CXCL1 signaling in dermal fibroblast orchestrates fibroblast-associated itch.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Machine Learning Analysis Classifies Patients with Primary Angle-Closure Glaucoma Using Abnormal Brain White Matter Function.

Clinical ophthalmology (Auckland, N.Z.)·2024
Same author

Altered functional connectivity between the default mode network in primary angle-closure glaucoma patients.

Neuroreport·2024
Same author

Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch.

Frontiers in molecular neuroscience·2023
Same author

Comparisons of artificial intelligence algorithms in automatic segmentation for fungal keratitis diagnosis by anterior segment images.

Frontiers in neuroscience·2023

Related Experiment Video

Updated: Aug 9, 2025

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping
07:11

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

1.7K

Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma.

Dong-Jin Li1, Bing-Lin Huang2, Yuan Peng3

  • 1Health Management Center, The First People's Hospital of Jiujiang City, Jiujiang, Jiangxi, China.

Frontiers in Neuroscience
|February 23, 2023
PubMed
Summary

Primary angle-closure glaucoma (PACG) patients exhibit altered dynamic functional connectivity (dFC) in the primary visual cortex (V1). This study reveals increased dFC within the visual network, suggesting potential functional changes in PACG.

Keywords:
dynamic functional connectivityfunctional magnetic resonance imagingmachine learningprimary angle-closure glaucomaprimary visual cortex

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.4K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.5K

Related Experiment Videos

Last Updated: Aug 9, 2025

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping
07:11

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

1.7K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.4K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.5K

Area of Science:

  • Neuroscience
  • Ophthalmology

Background:

  • Glaucoma is a leading cause of blindness globally.
  • Previous studies indicate glaucoma affects optic nerve pathways and visual cortex function, but dynamic changes remain unclear.

Purpose of the Study:

  • To investigate dynamic functional connectivity (dFC) changes in the primary visual cortex (V1) of patients with primary angle-closure glaucoma (PACG).

Main Methods:

  • Utilized a sliding window method to analyze dFC in 34 PACG patients and 34 healthy controls (HCs).
  • Focused analysis on the primary visual cortex (V1) and its connections.

Main Results:

  • PACG patients demonstrated increased dFC between the left V1 and bilateral calcarine (CAL).
  • PACG patients also showed increased dFC between the right V1 and bilateral CAL.

Conclusions:

  • Patients with PACG exhibit increased dynamic functional connectivity within the visual network.
  • These findings suggest increased functional connectivity variability in the V1 of PACG patients.