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Interleukin 25 and its biological features and function in intestinal diseases
Wei Jiang1, Zehui Wang1, Jun Zhang1
1Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Central-European Journal of Immunology
|February 23, 2023
Summary
Interleukin 25 (IL-25) is a key regulator of type 2 immunity, influencing intestinal health and disease. This review explores IL-25
Area of Science:
- Immunology
- Gastroenterology
Background:
- Interleukin 25 (IL-25), also known as IL-17E, is a cytokine within the IL-17 family.
- IL-25 is a critical regulator of type 2 immune responses.
- Emerging evidence highlights IL-25's complex roles in various organs and its interactions with diverse cell types.
Purpose of the Study:
- To review the current understanding of Interleukin 25 (IL-25) biology.
- To elucidate the cellular sources, targets, and signaling pathways of IL-25.
- To examine IL-25's involvement in intestinal diseases and its therapeutic potential.
Main Methods:
- Literature review of existing studies on IL-25.
- Analysis of IL-25's role in various intestinal conditions.
- Exploration of IL-25 signaling mechanisms.
Main Results:
- IL-25, produced by intestinal epithelial cells, significantly impacts intestinal immunity.
- IL-25 is implicated in allergic reactions, autoimmune diseases, and colorectal cancer.
- IL-25 plays a role in helminth infection, inflammatory bowel diseases, and food allergies.
Conclusions:
- IL-25 is a multifaceted cytokine with significant implications for intestinal health and disease.
- Understanding IL-25's biology is crucial for developing novel therapeutic strategies.
- Further research into IL-25's role may unlock new treatments for various gastrointestinal disorders.
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