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Clinical Features, Treatment, and Outcome of Psittacosis Pneumonia: A Multicenter Study

Yueyan Ni1, Huanhuan Zhong2, Yu Gu1

  • 1Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, China.

Open Forum Infectious Diseases
|February 23, 2023
PubMed
Abstract

Insights

Psittacosis pneumonia often leads to severe illness. Metagenomic next-generation sequencing (mNGS) aids rapid diagnosis, with tetracyclines showing high efficacy and cure rates.

Area of Science:

  • Infectious Diseases
  • Respiratory Medicine
  • Clinical Microbiology

Background:

  • Psittacosis pneumonia is a significant respiratory illness, often associated with bird exposure.
  • This study describes clinical features and identifies risk factors for severe psittacosis pneumonia.
  • Understanding these factors is crucial for timely diagnosis and management.

Purpose of the Study:

  • To characterize psittacosis pneumonia cases.
  • To identify risk factors associated with severe disease progression.
  • To evaluate treatment efficacy and outcomes.

Main Methods:

  • A multicenter study involving 122 patients diagnosed with psittacosis pneumonia using metagenomic next-generation sequencing (mNGS).
  • Data collected from April 2018 to April 2022 across 15 tertiary hospitals in China.
  • Clinical, laboratory, and imaging findings were analyzed, along with treatment outcomes.

Main Results:

  • Common symptoms include fever, cough, and fatigue; severe pneumonia criteria were met by 42.6% of patients.
  • Age over 65 and male sex were identified as risk factors for severe psittacosis pneumonia.
  • Tetracycline therapy demonstrated higher effectiveness (95.7% vs 31.0%) and faster defervescence compared to fluoroquinolones.

Conclusions:

  • Psittacosis pneumonia frequently presents with severe disease, necessitating prompt diagnosis.
  • Metagenomic next-generation sequencing (mNGS) offers rapid and accurate diagnostic capabilities.
  • Tetracyclines are effective treatments, leading to high cure rates and rapid symptom resolution.
Keywords:
Chlamydia psittacicommunity-acquired pneumoniametagenomic next-generation sequencingpsittacosis pneumonia

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