Related Experiment Video
Updated: Aug 9, 2025

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
Published on: January 19, 2019
Biological Restraint on the Izhikevich Neuron Model Essential for Seizure Modeling
Beata Strack1, Kimberle M Jacobs2, Krzysztof J Cios3
1B. Strack is with the Department of Computer Science, Virginia Commonwealth University School of Engineering, Richmond, VA.
Abstract:
We propose a simple modification of the Izhikevich neuron model to restrict firing rates of neurons. We demonstrate how this modification affects overall network activity using a simple artificial network. Such restraint on the Izhikevich neuron model would be especially important in larger scale simulations or when frequency dependent short-term plasticity is one of the network components. Although maximum firing rates are most likely exceeded in simulations of seizure like activity or other conditions that promote excessive excitation, we show that restriction of neuronal firing frequencies has impact even on small networks with moderate levels of input.
Related Concept Videos
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Overview of Synapses

