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Updated: Aug 9, 2025
Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
Published on: September 5, 2018
Simulating lesions in multi-layer, multi-columnar model of neocortex
Beata Strack1, Kimberle M Jacobs2, Krzysztof J Cios3
1Department of Computer Science, Virginia Commonwealth University School of Engineering, Richmond, VA.
Abstract:
The paper presents results of modeling global and focal loss of layers in a multi-columnar model of neocortex. Specifically, the spread of activity across columns in conditions of inhibitory blockade is compared. With very low inhibition activity spreads through all layers, however, deep layers are critical for spread of activity when inhibition is only moderately blocked.
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