Asthma's effect on brain connectivity and cognitive decline
Frontiers in Neurology
|February 23, 2023
Summary
Asthma patients show altered brain connectivity. Dynamic voxel mirror homotopy connection (dVMHC) increased in visual networks but decreased in sensorimotor networks, impacting emotion and cognitive processing.
Area of Science:
- Neuroscience
- Medical Imaging
- Pulmonology
Background:
- Asthma is a chronic respiratory disease with potential neurological implications.
- Brain connectivity alterations may underlie cognitive and emotional deficits in asthma patients.
Purpose of the Study:
- To investigate changes in dynamic voxel mirror homotopy connection (dVMHC) between cerebral hemispheres in asthma patients.
- To explore the relationship between dVMHC and cognitive/emotional processing in asthma.
Main Methods:
- Case-control study with 31 asthma patients (BA) and 31 healthy controls (HC).
- Resting-state functional magnetic resonance imaging (rsfMRI) was used to assess dVMHC.
- dVMHC values were calculated between cerebral cortical regions.
Main Results:
- Asthma patients exhibited increased dVMHC in the visual network (lingual gyrus, calcarine sulcus).
- Decreased dVMHC was observed in the sensorimotor network (medial superior frontal gyrus, cingulate gyrus, supplementary motor area) in asthma patients.
- These changes correlated with reduced emotion regulation and visual/cognitive processing efficiency.
Conclusions:
- dVMHC analysis reveals significant alterations in brain connectivity in asthma.
- These findings suggest impaired visual and cognitive processing, and emotion regulation in asthma.
- dVMHC may serve as a biomarker for visual function, attention, and disease progression in asthma.
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