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Updated: Aug 9, 2025

DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning
Published on: May 10, 2024
SCovNet: A skip connection-based feature union deep learning technique with statistical approach analysis for the
Kiran Kumar Patro1, Jaya Prakash Allam2, Mohamed Hammad3
1Department of ECE, Aditya Institute of Technology and Management, Tekkali AP-532201, India.
Background And Objective:
The global population has been heavily impacted by the COVID-19 pandemic of coronavirus. Infections are spreading quickly around the world, and new spikes (Delta, Delta Plus, and Omicron) are still being made. The real-time reverse transcription-polymerase chain reaction (RT-PCR) is the method most often used to find viral RNA in a nasopharyngeal swab. However, these diagnostic approaches require human involvement and consume more time per prediction. Moreover, the existing conventional test mainly suffers from false negatives, so there is a chance for the virus to spread quickly. Therefore, a rapid and early diagnosis of COVID-19 patients is needed to overcome these problems.
Methods:
Existing approaches based on deep learning for COVID detection are suffering from unbalanced datasets, poor performance, and gradient vanishing problems. A customized skip connection-based network with a feature union approach has been developed in this work to overcome some of the issues mentioned above. Gradient information from chest X-ray (CXR) images to subsequent layers is bypassed through skip connections. In the script's title, "SCovNet" refers to a skip-connection-based feature union network for detecting COVID-19 in a short notation. The performance of the proposed model was tested with two publicly available CXR image databases, including balanced and unbalanced datasets.
Results:
A modified skip connection-based CNN model was suggested for a small unbalanced dataset (Kaggle) and achieved remarkable performance. In addition, the proposed model was also tested with a large GitHub database of CXR images and obtained an overall best accuracy of 98.67% with an impressive low false-negative rate of 0.0074.
Conclusions:
The results of the experiments show that the proposed method works better than current methods at finding early signs of COVID-19. As an additional point of interest, we must mention the innovative hierarchical classification strategy provided for this work, which considered both balanced and unbalanced datasets to get the best COVID-19 identification rate.
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